What's wrong?
怎么啦？
 

A : What's wrong? You look quite angry.
B : I just got a poor grade on my English exam.
A : 怎么啦？你看起来相当生气。
B : 我刚刚拿到一个很烂的英文考试成绩。

A : I am sorry, but I cannot go to work today.
B : What's wrong? Do you feel sick?
A : 不好意思，我今天不能去上班。
B : 怎么啦？你身体不舒服吗？